Unisom is a widely used over-the-counter medication aimed at providing relief from occasional sleeplessness. Its effectiveness is largely due to its active ingredient, diphenhydramine hydrochloride, an antihistamine commonly found in sleep aids and allergy medications.
What is Diphenhydramine Hydrochloride?
Diphenhydramine hydrochloride is a first-generation antihistamine that works by blocking histamine receptors in the brain. Histamines are chemicals involved in your body’s immune response, but they also play a role in regulating sleep. By inhibiting histamines, diphenhydramine induces drowsiness, making it easier for users to fall asleep.
How Does Diphenhydramine Work?
The sedative effects of diphenhydramine are a result of its ability to cross the blood-brain barrier and bind to H1 receptors in the brain. This action prevents the binding of histamine, a neurotransmitter that promotes wakefulness. Consequently, diphenhydramine reduces the alertness levels, facilitating the onset of sleep.
Usage and Dosage
Unisom SleepGels, one of the popular formulations, typically contain 50 mg of diphenhydramine hydrochloride per capsule. It is generally recommended for adults and children over the age of 12. The usual dosage is one capsule taken 30 minutes before bedtime. It’s important to follow the recommended dosage and not to exceed it, as overuse can lead to tolerance and diminished effectiveness over time.
Safety and Precautions
While diphenhydramine is effective in promoting sleep, it is not without side effects. Common side effects include dry mouth, dizziness, and constipation. More serious side effects can occur with misuse or overuse, such as confusion, blurred vision, and urinary retention. It is also advised to avoid alcohol and other central nervous system depressants while using Unisom, as these can enhance drowsiness and potentially lead to dangerous sedation levels.
Diphenhydramine hydrochloride, the active ingredient in Unisom, is a powerful antihistamine that offers effective relief from occasional sleeplessness. However, like any medication, it should be used responsibly and according to the recommended guidelines to ensure both safety and efficacy
